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{"account_id":137,"account_name":"WADOH","id":221,"status":"published","active":"1","password_protected":"1","password":"InfluentialAdults","name":"Under the Influence...Of You.","title":"","slug":"under-the-influence-of-you","profile_image":"https:\/\/\/\/wadoh\/WADOHUnderTheInfluenceToolkitHeader100417v2.png","full_image":null,"main_color":"#71accb","link_color":"","link_hover_color":"","display_alert":"1","alert_heading":"How to Use this Toolkit","center_alert_heading":null,"alert_content":"<p>1 in 5 Washington 10th graders reported using marijuana in the past 30 days. Marijuana can change the way a teen’s mind and body perform, which affects memory, learning, mood, motivation, coordination, and judgment. The Washington State Department of Health (DOH) is relaunching a statewide campaign, <em>Under the Influence...Of You<\/em>, to encourage influential adults to talk to the teens in their lives about the risks and consequences of using marijuana. And we need your help.<\/p>\r\n<h6>5 Things You Can Do<\/h6>\r\n<p>Here’s what you can do to help influential adults prevent youth marijuana use in our state.<\/p>\r\n<ol>\r\n<li><strong>Share campaign content on your organization’s social media channels<\/strong>. There are prepared posts below with messages, images, and videos to share on your social media channels, along with links to helpful resources and, where adults can learn more.<\/li>\r\n<li><strong>Distribute <em>Under the Influence...Of You<\/em> materials<\/strong>. Printed posters can be ordered at ADAI Clearinghouse. Put these up on bulletin boards or in windows. Place the flyers in waiting areas, and send them home with parents.<\/li>\r\n<li><strong>Prepare your staff to talk about the campaign and the facts<\/strong>. Campaign talking points and a backgrounder are available below. Download these and send them to staff with a link to the rest of this toolkit or dedicate time during your next staff meeting to review them.<\/li>\r\n<li><strong>Share the campaign through your organization’s newsletter<\/strong>. A drop-in newsletter blurb is available below. Your subscribers are already tuned in to your communications and are eager to help influential adults talk to youth about risks and consequences of marijuana.<\/li>\r\n<li><strong>Show campaign videos in local theaters.<\/strong> We’ve made four theater-ready campaign videos available for your use. Local movie theaters often donate unused ad space to organizations to show public service advertising.<\/li>\r\n<\/ol>\r\n<p>For more information or to request the password for this toolkit, please contact Kristen Haley at <a href=\"\" target=\"_blank\"><\/a>.<\/p>","alert_background_color":"#6d637d","alert_heading_color":"","alert_text_color":"","alert_link_color":"","alert_link_hover_color":"","instagram_url":"","twitter_url":"http:\/\/\/WADeptHealth","facebook_url":"http:\/\/\/WADeptHealth\/","google_plus_url":"","tumblr_url":"","pinterest_url":"","youtube_url":"https:\/\/\/user\/WADepartmentofHealth","vine_url":"","snapchat_url":"","contacts":"","key_dates":"","hashtags":"","brand_title":"","brand_description":"","brand_facebook":"","brand_tweets":"","brand_instagrams":"","brand_templates":"","brand_assets":"","campaigns":"440","sortorder":1,"view_count":2593,"created_at":"2017-09-18 14:08:26","updated_at":"2018-07-07 14:52:11"}

How to Use this Toolkit

1 in 5 Washington 10th graders reported using marijuana in the past 30 days. Marijuana can change the way a teen’s mind and body perform, which affects memory, learning, mood, motivation, coordination, and judgment. The Washington State Department of Health (DOH) is relaunching a statewide campaign, , to encourage influential adults to talk to the teens in their lives about the risks and consequences of using marijuana. And we need your help.

5 Things You Can Do

Here’s what you can do to help influential adults prevent youth marijuana use in our state.

For more information or to request the password for this toolkit, please contact Kristen Haley at .

Share campaign content on your organization’s social media channels



Project Managers



Trial Design


Nov 03, 2017
By Scott Hamilton, PhD
Applied Clinical Trials

Most statisticians would agree that dynamic randomization results in superior treatment group balancing over list-based stratified permuted blocked randomization, thereby increasing the precision in a randomized clinical trial. There have been several studies and review articles that provide ample evidence in favor of dynamic randomization.

However, in our routine interactions with statisticians and clinical trial managers, we continue to encounter the perception that dynamic randomization carries extra risk and complexity. We argue that from the implementation side of dynamic randomization, today’s modern computing platforms, thorough validation techniques, and robust randomization systems alleviate technical risk. From a regulatory perspective, dynamic randomization has been well received at the FDA for many years. We have worked on clinical trials where the FDA has explicitly requested dynamic randomization over list-based permuted blocked randomization. Any perceived regulatory risk when using dynamic randomization may be leftover from attitudes at European regulatory authorities, for example, the Committee on Proprietary Medicinal Products (CPMP). This stems from a European guidance document issued in 2003 that carried the opinion that dynamic randomization was “controversial.” However, because of excellent responses to that guidance document, and increased familiarity from more frequent use of dynamic randomization over the past 12 years, the perception of this risk has diminished. Thus, the hesitancy to utilize the benefits of dynamic randomization could arise from the perceived complexity. This may be due to a lack of familiarity with the process for choosing the randomization parameters and how to implement the algorithm for randomization in clinical trials.

The motivation for this article was to dissipate the perceptions of complexity by elucidating the details of our process for choosing the randomization parameters. We also provide guidance for how we implement dynamic randomization for clinical trials in randomization and trial supply management (RTSM) systems.

We begin by comparing the parameters for stratified permuted block randomization with those required for dynamic randomization. When designing a stratified permuted block randomization, the statistician must determine the stratification factors, their levels, and the block size. To maximize statistical power, the statistician desires to preserve the treatment group ratio(s) among all groups of subjects defined by demographic and disease characteristics that affect the outcome. The statistician must obtain the information about these groups from clinicians so that he or she can define the stratification factors and levels. The person also must obtain a relative hierarchy of importance for each factor for two reasons. Firstly, most methods of dynamic randomization allow for weighting of the stratification factors so that imbalances among factors with greater weight get brought back into balance more quickly. Some algorithms explicitly balance in hierarchical order among the factors. Secondly, in permuted block randomization there are practical limits to how many stratification factors can effectively be used before the balancing performance breaks down. Given the relative importance of each factor, the statistician may recommend dropping the ones that aren’t as important if there are too many. In most cases, the important factors are correlated and balancing on one factor will achieve balance on other correlated factors.

In permuted block randomization, choosing the block size is a trade‐off between the ability to maintain the blind and the efficiency of balancing the treatment groups. The larger the block size, the less chance there is that a pattern can be detected in the treatment group allocation. However, the larger the block size, the greater the probability of treatment group imbalances over the entire study as well as within stratification factor levels. In fact, the probability of imbalances is proportional to the number of strata and the block size. The convention is to use 2 times the sum of the treatment group ratio. For instance, in a two-treatment group study with a 1:1 ratio, the most common block size chosen is 4. In a two-treatment group study with a 2:1 ratio, the most common block size chosen is 6. Because of the strong inclination among statisticians to follow this convention, it is extremely rare to base the choice of the block size on the results of quantifying the probability of treatment group imbalance for different block sizes.

When designing a dynamic randomization algorithm, all the same criteria apply for choosing the stratification factors as in permuted blocked randomization. However, there is much greater flexibility in the number of factors that one can effectively include in the dynamic randomization. Unlike permuted block randomization, which balances the th factor level within the (‐1)st factor level, …, dynamic randomization directly balances on the marginal distribution of each factor. This makes it possible to add more factors to the algorithm without greatly reducing the ability to balance among the other factors. When planning a dynamic randomization, there is no block size to choose from. One must choose whether the allocation will be deterministic (minimization) or based on a biased‐coin toss. However, because of the opinion in the ICH‐9 guidance, it is generally advised to use a biased‐coin. Then the probability of the biased coin has to be chosen, e.g., for two treatment groups: 75/25, 80/20, 85/15, etc. Lastly, if weights will be applied to the stratification factors, the sizes of the weights need to be chosen. The next few paragraphs describe our process for choosing the biased‐coin probabilities and the weights.

Similar to choosing the block size in permuted block randomization, choosing the biased‐coin probability is a trade‐off between efficiently balancing the treatment groups and the level of randomness in the treatment allocation. The extremes in the biased‐coin spectrum are fair coin on one end to deterministic on the other. To make the choice, we simulate all possible enrollment patterns into the study under a range of biased‐coin probabilities and compare the balancing characteristics for each choice. For even treatment group allocation ratios, e.g. 1:1, 1:1:1, 1:1:1:1, we look at the distribution of absolute treatment group differences overall and within each factor level. For 2:1, 3:1, 4:1, etc., we look at treatment group ratios. After calculating the treatment group differences/ratios over all possible enrollment patterns, we may summarize them using a plot. An example is given in Figure 1.

The plot is meant to illustrate the imbalance measures for the overall study averaged over all the simulations for various biased‐coin probabilities. In this example, it shows a clear monotonic decrease in the imbalance between the treatment groups. However, one can see the greatest decrease in imbalance when going from a biased‐coin probability of 0.8 to 0.85. A statistician could use this as a rationale for choosing a biased‐coin probability of 0.85 since there is a marked decrease in imbalance from 0.8, but no worthwhile decrease at 0.9 or 0.95. The same would be constructed and examined within each stratum.

The advantage to using Monte‐Carlo simulations of enrollment is that we can realistically model all possible randomization order patterns within each stratum and overall. We customize the enrollment parameters to fit the study. For instance, one of the stratification factors may be electrocorticogram (ECOG) status 0‐1, vs. 2‐3, where 80% of the subjects enrolled will have an ECOG of 2‐3. We replicate that breakdown in our Monte‐Carlo simulations so that the imbalance statistics calculated from the simulation data accurately reflect what could happen in the proposed trial. When site is a stratification factor, the sponsor usually has a good idea of the number of sites, but not how many subjects each site will enroll. We have a large database of studies with many different numbers of sites and their patterns of enrollment. We use that database, the sample size, and the number of sites to create a realistic site enrollment pattern for use in the Monte‐Carlo simulations.

As previously mentioned, stratification factors typically have a hierarchical level of importance. For instance, it may be more important to maintain treatment group balance within ECOG score levels than gender. In this case, the statistician can specify weights that will correct ECOG stratum imbalances more quickly than imbalances within gender level. The tools for choosing the weights also utilize the simulations previously discussed. Essentially, we try out a few sets of weights and examine the imbalance measures. Figure 2 illustrates how this is done. The example is a 100-subject study with three 2‐level stratification factors with a 2:1 active:placebo ratio. The plot on the left in Figure 2 shows a dot for each simulation showing the number of randomized subjects within one of the ECOG strata. The X‐axis indicates the number randomized to Active and the Y‐axis to Placebo. With near perfect balancing, we would see a tight cloud of points around a line with a slope of 0.5.

The simulations show us that with the parameters of this randomization plan, we are obtaining a slope close to 0.5, and a measure of dispersion of 0.54. The medians show that on average there is an almost perfect 2:1 ratio. The plot on the right in Figure 2 shows the results of applying a weight of 10 to this factor. By adding the weight, the dispersion is reduced by 11.4% to approximately 0.48. The tightening of the ratios around 0.5 is evidenced visually as well. This may provide sufficient evidence that by weighting the ECOG stratification factor, we can effectively improve the consistency of the desired 2:1 ratio.

Of course, the statistician would want to look at the same plots of the other factors, such as gender, to determine the impact of adding the weight to the ECOG factor on the other factors. As an illustration, this is shown in Figure 3 for male gender. The increase in dispersion within the treatment group ratios within males after applying a weight to ECOG is approximately 520%. The increase in dispersion in treatment group balance among the males by adding the weight to ECOG may outweigh the reduction in dispersion within the ECOG strata. However, the relative importance of achieving balance within gender may be far lower than balance within ECOG score, in which case this scenario may be acceptable. The answer is always driven by the clinical science of the therapeutic area. The statistician has to tune these balancing parameters with the science to maximize the precision of the study.

In this article, we have provided an overview of our quantifiable techniques for choosing the parameters in dynamic randomization. Prior to the start of a study, a statistician must make plenty of decisions regarding power, analysis methods, handling missing data, etc. Adding more certainty to the randomization plan is of great help to the statistician. As with most statistical techniques, we find that when a statistician has experienced the quantitative process for choosing the randomization parameters for the first time, the mystery greatly dissipates and confidence grows. A statistician is most confident when he or she has quantified evidence from data to support their decisions. Fortunately, we have a sound process, a wealth of experience, and the data from thousands of randomized studies for statisticians to develop dynamic randomizations that will increase the precision of their studies.

At Bracket, our mission is to bring quality, resourcefulness, and dependability to the medicine development process. Improvements in the ability to implement sound and robust dynamic randomization systems provide us an easy landscape to utilize modern simulation techniques and graphical displays of quantitative data for making decisions about the biased‐coin probabilities and weights. Future discussions will explore more subtle and flexible methods to biased‐coin and weighting in dynamic randomization.


1. McEntegart, D.J. “The Pursuit of Balance Using Stratified and Dynamic Randomization Techniques: An Overview,” , 37 (3) 293–308 (2003).

2. Buyse, M., McEntegart, D.J, “Achieving Balance in Clinical Trials: An Unbalanced View from EU Regulators, “ , May 2004

3. Therneau TM. “How many stratification factors are “too many” to use in a randomization plan?” 1993; 14:98‐108.

4. Kalish LA, Begg CB. “Treatment allocation methods in clinical trials: A review.” 1985; 4:129‐144.

5. CPMP, C. f. (2003). “Points to Consider on Adjustment for Baseline Covariates.”

6. Hodges, D. B. (1957). “Design for the Control of Selection Bias.” , 28: 449‐460.

7. McEntegart, D. (2008). “Blocked Randomization.” In R. S. D'Agostino, (p. DOI:10.1002/9780471462422.eoct301). Hoboken: John Wiley Sons, Inc.

8. Ledford D, Busse W, Trzaskoma B, Omachi TA, Rosén K, Chipps BE, Luskin AT, Solari PG.J. “A Randomized Multicenter Study Evaluating Xolair Persistence of Response After Long‐Term Therapy.". 2016 Nov 5. pii: S0091‐6749(16)31274‐X. doi: 10.1016/j.jaci.2016.08.054

Scott Hamilton

Your fish dinner probably suffocated on the deck of a ship — a slow and painful death #FriendsNotFood

Gonna be really hard for me to stop eating seafood. Been a pescetarian for 9 months now. Pescetarian was my first step into going vegan. Now working on seafood and dairy.

1 day ago · 7

Stopped eating meat and seafood a year ago. Not an easy thing to do in Cajun county, but I feel so much better!

1 day ago · 5

It's common sense.....EVERYTHING FEELS PAIN!

1 day ago · 2

Am I crazy, or isn't it plainly obvious that fish have the capacity to feel pain?

1 day ago · 5

It is terrible that we need evidence to show that fish feel pain.... shouldn't it be obvious???

22 hours ago · 1

I figured that out a long time ago. Stopped eating fish in 1996

1 day ago · 3

Umm...How do people not know that fish feel pain?

1 day ago · 3

I've never eaten Seafood in my entire life and I never will..

1 day ago · 1

When you look at a piece of fish on your plate or in a tin, how can you not see how it was caught, suffered and died just to be eaten. How can you catch another living creature, kill it and it eat without feeling remorse or guilt knowing that they have feelings and suffered tremendously before finally dieting in fear and immense pain?

23 hours ago · 1

Y'all are so stupid guess your plants that you eat have feelings to right that will be the next thing I see or hear re re

23 hours ago

That’s why I am vegan! Simple compassion over cruelty!

1 day ago · 2

I cant believe this is even news.... how is it possible that we can find cures for diseases, but people don't think fish feel pain?

11 hours ago

Not according to.the UK government. They've ruled that they aren't sentient-except pets, apparently!

1 day ago · 1

Rahul Gandhi see I told you.. looks like this is the worst

22 hours ago

some real sickos in the world - of course everything that breathes will feel pain - disgusting humans

6 hours ago

I love fish!! Y u m m y

22 hours ago
15 hours ago · 1

Fish were made for eating

4 hours ago

Dom Duff sorry not sorry

1 day ago

Of course they feel pain, baffles me how ignorant people are. Stop eating animals

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The Save Movement

1 day ago

The Save Movement shared Jane Velez-Mitchell's live video. Jane Velez-Mitchell#JaneUnChained LIVE at a pig slaughterhouse near downtown LA during a record breaking heatwave where temperatures hit 117 degrees in some areas. Pigs, tightly packed in trucks are driven long distances without food or water. The sweltering heat makes a nightmarish ride even more ... Oscar de la Renta Suede Bow KneeHigh Boots buy cheap discounts u73uQp

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